Evolution of the mouse polyubiquitin-C gene |
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Authors: | Perelygin Andrey A Kondrashov Fyodor A Rogozin Igor B Brinton Margo A |
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Affiliation: | (1) Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30303, USA, US;(2) National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA, US |
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Abstract: | The polymeric ubiquitin (poly-u) genes are composed of tandem 228-bp repeats with no spacer sequences between individual monomer units. Ubiquitin is one of the most conserved proteins known to date, and the individual units within a number of poly-u genes are significantly more similar to each other than would be expected if each unit evolved independently. It has been proposed that the rather striking similarity among poly-u monomers in some lineages is caused by a series of homogenization events. Here we report the sequences of the polyubiquitin-C (Ubc) genes in two mouse strains. Analysis of these sequences, as well as those of the previously reported Chinese hamster and rat poly-u genes, supports the assertion that the homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-over events. The sequence divergence of noncoding DNA was used to estimate the frequency of unequal crossing-over events (6.3 × 10−5 events per generation) in the Ubc gene, as well as to provide evidence of apparent selection in the poly-u gene. |
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Keywords: | : Concerted evolution — Purifying selection — Ubiquitin — Multigene family — Unequal crossing-over — Apparent selection |
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