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Role of lipoperoxidation in aflatoxin production
Authors:S Passi  M Nazzaro-Porro  C Fanelli  A A Fabbri  P Fasella
Institution:(1) Istituto San Gallicano, Via San Gallicano, Rome, Italy;(2) Dipartimento di Biologia vegetale, Università di Roma lsquoLa Sapienzarsquo, Largo Cristina di Svezia 24, 00165 Rome, Italy;(3) Cattedra di Chimica Biologica, Università di Roma lsquoTor Vergatarsquo, Rome, Italy
Abstract:Summary Lipoperoxidation appears to play a role in inducing aflatoxin biosynthesis. In vitro, synthetic lipoperoxides greatly stimulate aflatoxin production when added to cultures of toxigenic strains of Aspergillus parasiticus or A. flavus. In vivo, the amount of toxin formed in sunflower seeds of different ages inoculated with A. parasiticus is directly related to the peroxide number of their oil content: the higher the peroxide number, the higher the aflatoxin production. In cultures of A. parasiticus carbon tetrachloride (CCl4) greatly stimulates aflatoxin biosynthesis. This effect might be due to the peroxidation of lipids of the endoplasmic reticulum of Aspergillus by the highly reactive CCl . 3 radicals formed by interaction with the NADPH-cytochrome P-450 system.
Keywords:
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