| 多肽噬菌体展示 |
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| 引用本文： | 唐为钢,甘人宝,王克夷. 多肽噬菌体展示[J]. 生物化学与生物物理进展, 1997, 24(3): 203-207 |
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| 作者姓名： | 唐为钢 甘人宝 王克夷 |
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| 作者单位： | 中国科学院上海生物化学研究所，上海 200031;中国科学院上海生物化学研究所，上海 200031;中国科学院上海生物化学研究所，上海 200031 |
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| 摘 要： | 噬菌体展示技术已被广泛地应用于生物学研究的各个方面.利用它可融合表达多肽、蛋白质结构域和蛋白质.尤其是多肽噬菌体展示,已被作为一种便利的研究工具去发现和研究那些与受体、酶、凝集素、抗体、核酸以及其他生物分子亲和的多肽配基和酶的底物专一性，该技术在药物的发现，疫苗的设计等医学领域也有着潜在的应用价值.
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| 关 键 词： | 噬菌体展示 固定化的靶分子，多肽噬菌体展示 |
| 收稿时间： | 1996-05-07 |
| 修稿时间： | 1996-10-21 |
Peptide Phage Display |
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| TANG Weigang,GAN Renbao and WANG Keyi. Peptide Phage Display[J]. Progress In Biochemistry and Biophysics, 1997, 24(3): 203-207 |
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| Authors: | TANG Weigang GAN Renbao WANG Keyi |
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| Affiliation: | Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China;Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China;Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China |
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| Abstract: | Recently, phage display techniques have been applied to various biological aspects. Phage can be exploited to display peptides, protein domains and proteins on its surface. Especially peptide phage display is now well established as a tool for the search for peptides binding to antibodies, enzymes, receptors, lectins, nucleic acids or other target molecules and in studying the substrate specificity of enzymes. It has great potential for application in the areas of drug discovery, vaccine development and other pharmaceutical development. |
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| Keywords: | phage display immobilized target peptide phage display |
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