A study of the relationships between carbon tetrachloride-induced lipid peroxidation and liver damage in rats pretreated with vitamin E |
| |
Authors: | Angelo Benedetti Marco Ferrali Elisabetta Chieli Mario Comporti |
| |
Institution: | Istituto di Patologia Generale dell''Università di Pisa, Scuola Medica, Via Roma 55, 56100 Pisa Italy |
| |
Abstract: | The relationships between the peroxidation of musomal lipids and the early liver damage have been investigated in rats pretreated with progressively higher doses of α-tocopherol (vit. E) and intoxicated with various amounts of carbon tetrachloride.Pretreatment of rats with vit. E at 25 body wt. has minor effects on both the peroxidation of musomal lipids and the liver triglyceride accumulation in rats poisoned with CC14 at 250 body wt. However, a decrease of the peroxidative reaction and of the liver steatosis occurs when the rats are pretreated with progressively higher doses of vit.E. A close correlation exists between the two phenomena, when the intoxication is accomplished with CC14 at 250 body wt. Also, the musomal concentration of α-tocopherol is strictly correlated to both the decrease of musomal lipoperoxidation and the decrease of liver triglyceride accumulation. The CCl4-induced impairment of musomal glucose-6-phosphatase and the incorporation of 14C from 14CC14 into liver musomal lipids are not affected by vit. E pretreatment.The extent of musomal lipoperoxidation is not correlated to the liver triglyceride accumulation when vit. E-pretreated rats are given CC14 at 25 or 2.5 body wt. However, a correlation between lipoperoxidation and liver steatosis occurs when non-pretreated rats are challenged with the three different doses of the halogenated hydrocarbon. |
| |
Keywords: | DPPD G6P-ase glucose-6-phosphatase |
本文献已被 ScienceDirect 等数据库收录! |