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Non-coding regions of the Ebola virus genome contain indispensable phylogenetic and evolutionary information |
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| Authors: | XinQuan Jiang ZhenJie Zhang DongMing Zhuang Michael J Carr RuiLing Zhang Qiang Lv WeiFeng Shi |
| Institution: | 1.School of Public Health,Taishan Medical College,Tai’an,China;2.Institute of Pathogen Biology,Taishan Medical College,Tai’an,China;3.National Virus Reference Laboratory,University College Dublin,Dublin 4,Ireland |
| Abstract: | We compared the numbers of nucleotide substitutions occurring in the non-coding regions and coding regions of Ebola virus genomes and found that non-coding regions contain indispensable phylogenetic and evolutionary information. The omission of genetic data from non-coding regions can lead to unreliable phylogenies and inaccurate estimates of evolutionary parameters. |
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