Porphyrin mutants of : Correlated lesions in sterol and fatty acid biosynthesis |
| |
Authors: | M. Bard R.A. Woods J.M. Haslam |
| |
Affiliation: | Department of Genetics University of Sheffield Sheffield, S10 2TN UK;Department of Biochemistry University of Liverpool Liverpool L69 3BX UK |
| |
Abstract: | The , and mutants of yeast require an unsaturated fatty acid and methionine for growth and do not synthesise ergosterol. They have very similar sterol compositions and all accumulate lanosterol. The mutants lack cytochrome pigments and have negligible respiratory activity. Porphyrin intermediates alleviate the lipid requirement of and and restore respiratory competence. It is concluded that the primary defects in these mutants are lesions in porphyrin biosynthesis. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |