Sitting and Supine Esophageal Pressures in Overweight and Obese Subjects

Esophageal pressure (P_Es) can be used to approximate pleural pressure (P_pl) and might be clinically useful, particularly in the obese e.g., to guide mechanical ventilator settings in critical illness. However, mediastinal artifact (the difference between true P_pl and P_Es) may limit acceptance of the measurement, and reproducibility of P_Es measurements remains unknown. Therefore, we aimed to assess the effect of body posture on P_Es in a cohort of obese, but healthy subjects, some of whom had multiple measurements, to address the clinical robustness of esophageal manometry. Twenty‐five overweight and obese subjects (BMI > 25 kg/m²) and 11 control lean subjects (BMI < 25 kg/m²) underwent esophageal manometry with pressures measured seated and supine. Twenty overweight and obese subjects had measurements repeated after ～1 to 2 weeks. Anthropometric data and sitting and supine spirometry were recorded. The average end‐expiratory P_Es sitting and supine were greater in the overweight and obese group than the lean group (sitting ?0.1 ± 2.1 vs. ?3.3 ± 1.2 cmH₂O, supine 9.3 ± 3.3 vs. 6.9 ± 2.8 cmH₂O, respectively). The mean differences between repeated measurements were small (?0.3 ± 1.7 cmH₂O sitting and ?0.1 ± 1.5 cmH₂O supine). P_Es correlated with a number of anthropometric and spirometric variables. In conclusion, P_Es are slightly greater in overweight and obese subjects than lean subjects; but changes with position are similar in both groups. These data indicate that mediastinal weight and postural effects on P_Es are within a clinically acceptable range, and suggest that esophageal manometry can be used to inform clinical decision making across wide range of body types.