Differential effects of metabolic inhibitors on cytoplasmic membrane associated and nuclear DNA |
| |
| Authors: | M.R. Hall W. Meinke D.A. Goldstein R.A. Lerner |
| |
| Affiliation: | 1. Department of Microbiology, Scripps Clinic and Research Foundation, La Jolla, California 92037 USA;2. Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037 USA |
| |
| Abstract: | The cellular functions necessary for transport of cytoplasmic membrane associated DNA from nucleus to cytoplasm have been investigated utilizing inhibitors of macromolecular synthesis. Hydroxyurea, fluorodeoxyuridine, cytosine arabinoside, and ethidium bromide did not prevent transport of cytoplasmic membrane associated DNA to the cytoplasm. In contrast, rifampicin and N-demethyl rifampicin totally inhibited the appearance of newly synthesized DNA on cytoplasmic membranes, while dimethyl-benzyl-demethyl rifampicin was partially inhibitory. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
