Fragile X mental retardation protein in learning-related synaptic plasticity |
| |
Authors: | Valentina Mercaldo Giannina Descalzi Min Zhuo |
| |
Institution: | (1) Department of Biological Sciences, Kennedy Center for Research on Human Development, Vanderbilt University, 6270 MRB III, 465 21st Avenue South, Nashville, TN 37232, USA; |
| |
Abstract: | Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein (FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to contribute to synaptic plasticity by regulating plasticity-related protein
synthesis and other signaling pathways. Previous studies have mostly focused on the roles of FMRP within the hippocampus -
a key structure for spatial memory. However, recent studies indicate that FMRP may have a more general contribution to brain
functions, including synaptic plasticity and modulation within the prefrontal cortex. In this brief review, we will focus
on recent studies reported in the prefrontal cortex, including the anterior cingulate cortex (ACC). We hypothesize that alterations
in ACC-related plasticity and synaptic modulation may contribute to various forms of cognitive deficits associated with FXS. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|