Synthesis and characterization of thermosensitive graft copolymer of N-isopropylacrylamide with biodegradable carboxymethylchitosan |
| |
Authors: | Hou-feng Zhang Hui Zhong Li-li Zhang Sai-bo Chen Yi-jiang Zhao Yu-lan Zhu |
| |
Affiliation: | aJiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, Department of Chemistry, Huaiyin Teacher’s College, Huaian 223300, PR China;bCollege of Sciences, Nanjing University of Technology, Nanjing 210009, PR China |
| |
Abstract: | A novel thermosensitive and hydrogel was designed and synthesized by graft copolymerization of N-isopropylacrylamide (NIPAAm) with biodegradable carboxymethylchitosan (CMCS). The influence of the content of CMCS grafted on the properties of the resulted hydrogels was examined. The morphology of the hydrogels was observed by scanning electron microscopy (SEM), their thermal property was characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and deswelling/swelling kinetics upon external temperature changes. In comparison with the conventional PNIPAAm hydrogels, the resulted hydrogels have improved thermosensitive properties, including enlarged water content at room temperature and faster deswelling/swelling rate upon heating. The strategy described here presents a potential alternative to the traditional synthesis techniques for thermosensitive hydrogels. |
| |
Keywords: | Carboxymethylchitosan N-isopropylacrylamide Graft copolymerization Thermosensitivity |
本文献已被 ScienceDirect 等数据库收录! |
|