Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses. |
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| Authors: | J Jamison J Gilloteaux M R Nassiri C C Tsai J Summers |
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| Institution: | Department of Urology, Summa Health System/N.E. Ohio Universities College of Medicine, Rootstown 44272, USA. |
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| Abstract: | Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or poly (dG-dC).poly (dG-dC). Modulation of one or more nuclear (nucleolar) processes of the host cell may be responsible for the synergistic antiviral activity. |
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