Role of K(ATP) channels in protection against neuronal excitatory insults |
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Authors: | Soundarapandian Mangala M Zhong Xiaofen Peng Lisheng Wu Di Lu Youming |
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Affiliation: | Biomedical Science Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA |
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Abstract: | ATP-sensitive K+ (KATP) channels that are gated by intracellular ATP/ADP concentrations are a unique subtype of potassium channels and play an essential role in coupling intracellular metabolic events to electrical activity. Opening of KATP channels during energy deficits in the CNS induces efflux of potassium ions and in turn hyperpolarizes neurons. Thus, activation of KATP channels is thought to be able to counteract excitatory insults and protect against neuronal death. In this review, we bring together recent studies about what kinds of molecules are needed to build and regulate arrays of KATP channel functions in the CNS neurons. We propose a model to explain how KATP channel activation regulates glutamate release from the pre-synaptic terminals and how this regulation protects against ischemic neuronal injury and epilepsy. |
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Keywords: | epilepsy excitotoxicity glutamate ischemia KATP synaptic degeneration |
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