Changes in TWIK-related Acid Sensitive K+-1 and -3 Channel Expressions from Neurons to Glia in the Hippocampus of Temporal Lobe Epilepsy Patients and Experimental Animal Model |
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| Authors: | Kim Ji-Eun Yeo Seong-Il Ryu Hea Jin Chung Chun Kee Kim Min-Ju Kang Tae-Cheon |
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| Affiliation: | (1) Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea;(2) Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea;(3) Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, 110-744, South Korea;(4) Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea;(5) Present address: Department of Neurology, UCSF, and Veterans Affairs Medical Center, San Francisco, CA 94121, USA; |
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| Abstract: | In the present study, we analyzed expressions of tandem of P domains in a Weak Inwardly rectifying K+ channel (TWIK)-related Acid-Sensitive K+ (TASK) channel-1 and -3 in the hippocampus of patients with temporal lobe epilepsy (TLE) and in rat model. In the control human subjects, TASK-1, and -3 immunoreactivity was observed in pyramidal neurons and dentate granule cells. In TLE patients, TASK-1 and -3 immunoreactivity was rarely observed in neurons. However, TASK-1 immunoreactivity was observed in astrocytes, and TASK-3 immunoreactivity was detected in both astrocytes and microglia. In the rat hippocampus, TASK-1 immunoreactivity was observed in astrocytes within normal and epileptic hippocampus. The alterations in TASK-3 immunoreactivity in the rat hippocampus were similar to those in the human hippocampus. These findings reveal that TASK-1 and -3 are differentially expressed in the normal and epileptic hippocampus, and suggest that TASK channels may contribute to the properties of the epileptic hippocampus. |
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