Immunoreactive and bioactive somatostatin-like material is present in tobacco (Nicotiana tabacum) |
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Authors: | H Werner M Fridkin D Aviv Y Koch |
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Institution: | 1. Department of Hormone Research The Weizmann Institute of Science, Rehovot 76100, Israel;2. Department of Organic Chemistry The Weizmann Institute of Science, Rehovot 76100, Israel;3. Department of Plant Genetics The Weizmann Institute of Science, Rehovot 76100, Israel |
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Abstract: | Immunoreactive and biologically active somatostatin-like material is present in extracts of tobacco plants (Nicotiana tabacum). Comparative chromatographic and immunological characterization of this peptide along with synthetic (hypothalamic-like) somatostatin-14 and -28, indicates that both molecular forms are present in the plant. Tobacco-somatostatin inhibits the prostaglandin E2-induced release of growth hormone from cultured anterior pituitary cells. This finding raises questions concerning the evolutionary mechanisms responsible for the presence of this neuropeptide in plants, and the physiological significance of this phenomena. |
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Keywords: | Tobacco plants Immunoreactive and bioactive somatostatin Evolution of neuropeptides |
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