Synthesis of Haemoglobin Lepore |
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| Authors: | J M WHITE A LANG P A LORKIN H LEHMANN J REEVE |
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| Institution: | 1.MRC Abnormal Haemoglobin Unit, Department of Biochemistry,University of Cambridge,;2.Prince of Wales's General Hospital,London |
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| Abstract: | HAEMOGLOBIN Lepore is a class of haemoglobin variants composed of α-chains and hybrids of δ and β-chains, which can be designated as α2(δβ)2. The N-terminal amino-acid sequence of the hybrid chains corresponds to that of δ-chains, while the C-terminal sequence corresponds to that of β-chains. A misplaced synapse of the δ and β gene loci is thought to have occurred during meiosis, followed by a non-homologous cross-over1. Three types are known which differ in the position of the cross-over: Hb Lepore Hollandia2,3, Hb Lepore Baltimore4 and Hb Lepore Boston (Washington)5,6. |
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