Evolution of trappin genes in mammals |
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| Authors: | Akira Kato Alejandro P Rooney Yutaka Furutani Shigehisa Hirose |
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| Affiliation: | (1) Department of Biological Sciences, Tokyo Institute of Technology, Yokohama, Japan;(2) United States Department of Agriculture, National Center for Agricultural Research Utilization, Microbial Genomics Research Unit, USA;(3) Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama, Japan |
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| Abstract: | Background Trappin is a multifunctional host-defense peptide that has antiproteolytic, antiinflammatory, and antimicrobial activities. The numbers and compositions of trappin paralogs vary among mammalian species: human and sheep have a single trappin-2 gene; mouse and rat have no trappin gene; pig and cow have multiple trappin genes; and guinea pig has a trappin gene and two other derivativegenes. Independent duplications of trappin genes in pig and cow were observed recently after the species were separated. To determine whether these trappin gene duplications are restricted only to certain mammalian lineages, we analyzed recently-developed genome databases for the presence of duplicate trappin genes. |
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