Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype. |
| |
| Authors: | R P Roos S Stein M Routbort A Senkowski T Bodwell and R Wollmann |
| |
| Institution: | Department of Neurology, University of Chicago Pritzker School of Medicine, Illinois 60637. |
| |
| Abstract: | DA strain of Theiler's murine encephalomyelitis virus produces a persistent demyelinating infection. We previously produced escape mutant viruses that are resistant to a neutralizing monoclonal antibody and have a mutation in VP1 amino acid residue 268 in a neutralization site (Y. Ohara, A. Senkowski, J. Fu, L. Klaman, J. Goodall, M. Toth, and R.P. Roos, J. Virol. 62:3527-3529, 1988). In contrast to wild-type DA strain, these escape mutants produce little if any demyelinating disease after inoculation into weanling mice. |
| |
| Keywords: | |
|
|
