Repair deficiency in Escherichia coli UV-sensitive mutator strain uvr502 |
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Authors: | B I Sinzinis G B Smirnov A A Saenko |
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Institution: | 1. Research Institute of Medical Radiology, Academy of Medical Sciences of USSR, Obninsk, Kaluga Region USSR;2. Gamaleya Institute for Epidemiology and Microbiology, Academy of Medical Sciences, Moscow, USSR |
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Abstract: | The effect of ultraviolet irradiation (UV) has been studied in mutator UV-sensitive mutant , its derivative and wild-type strain. The mutant is about 5 times more UV-sensitive than the + isogenic strain, but 3 times less sensitive than the single mutant. Cells of the mutant are unable to rejoin the fragments of parental DNA formed after UV as a result of incision. The double mutant as well as the single mutant irradiated with UV is unable to introduce breaks into parental DNA. The extent of postreplication repair is essentially normal in the cells. There is no significant difference between the and cells in the rate and extent of UV-induced DNA degradation. |
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