Two-locus,fourth-order gene frequency moments: Implications for the variance of squared linkage disequilibrium and the variance of homozygosity |
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Authors: | G.B. Golding C. Strobeck |
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Affiliation: | Department of Genetics, University of Alberta, Edmonton, Alberta T6G 2E9, Canada |
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Abstract: | Identity coefficients are used to construct a sufficient set of equations to determine the fourth-order moments of gene frequencies for two linked loci. This allows the variance of the expected squared linkage disequilibrium to be found. It is shown that the coefficient of variation is generally greater than one and if the mutation rate is small, the standard deviation is more than four times the size of the mean. This demonstrates that squared linkage disequilibrium is a highly variable quantity. The variance of homozygosity for a gene which consists of two sites can also be obtained. Recombination between these sites increases the variance of homozygosity, suggesting that intragenic recombination significantly changes all the expected moments of gene frequencies if 4Nμ > 1.0 and r > μ (where N is the population size, μ is the mutation rate of the gene to neutral alleles, and r is the recombination rate between two sites within the gene). |
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