Polyaminen and brain injury |
| |
Authors: | N de Vera Ph D L Camón E Martínez |
| |
Institution: | (1) Department of Pharmacology and Toxicology, C.S.I.C, c/Jordi Girona 18-26, E-08034 Barcelona, Spain;(2) Department of Neurochemistry, Barcelona, Spain |
| |
Abstract: | Summary The cerebral ODC/polyamine system is disturbed by brain injury. The main modifications are important increases in ODC activity and putrescine concentration, with minor variations in spermidine and spermine concentrations. A great diversity of stimuli such as cerebral ischemia or overstimulation of the central nervous system by chemical or non-chemical agents can induce polyamine disturbances. Both the contribution of polyamines to the brain damage and their involvement in the repair mechanisms triggered after brain insults have been proposed. |
| |
Keywords: | Amino acids Putrescine Spermidine Spermine Brain damage Ischemia Convulsion |
本文献已被 SpringerLink 等数据库收录! |