Phospholipase D promotes Arcanobacterium haemolyticum adhesion via lipid raft remodeling and host cell death following bacterial invasion |
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| Authors: | Erynn A Lucas Stephen J Billington Petteri Carlson David J McGee B Helen Jost |
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| Affiliation: | 1.Department of Veterinary Science and Microbiology,The University of Arizona,Tucson,USA;2.Department of Bacteriology and Immunology, Haartman Institute,University of Helsinki,Helsinki,Finland;3.Department of Microbiology and Immunology,Louisiana State University Health Sciences Center-Shreveport,Shreveport,USA;4.Modesto Junior College,Modesto,USA;5.Ventana Medical Systems, Inc.,Oro Valley,USA;6.Office for the Responsible Conduct of Research,The University of Arizona,Tucson,USA |
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| Abstract: | Background Arcanobacterium haemolyticum is an emerging bacterial pathogen, causing pharyngitis and more invasive infections. This organism expresses an unusual phospholipase D (PLD), which we propose promotes bacterial pathogenesis through its action on host cell membranes. The pld gene is found on a genomic region of reduced %G + C, suggesting recent horizontal acquisition. |
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