Stretch-activated ion channels in cultured mesangial cells |
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Authors: | W Craelius N el-Sherif C E Palant |
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Affiliation: | Department of Medicine, Veterans' Administration Medical Center, Brooklyn, NY 11209. |
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Abstract: | Membrane stretch, delivered by negative pressures in cell-attached patch pipettes, activated single-channel ionic currents in cultured mesangial cells. Channel opening probabilities were directly related to degree of suction, with threshold for activation being 5-10 mm Hg. The stretch-activated channels were permeable to Na+, K+, as well as Cl-, having conductances averaging 62 +/- 17 pS. These channels may represent a cellular mechano-reflex in mesangial cells. |
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