Sequential events of apoptosis involving docetaxel, a microtubule-interfering agent: A cytometric study |
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| Authors: | Francesco Fabbri Silvia Carloni Giovanni Brigliadori Wainer Zoli Rosa Lapalombella Marina Marini |
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| Institution: | (1) MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK;(2) Division of Signal Transduction Therapy, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK |
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| Abstract: | Background Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1
and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several
human cancers. |
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