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Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulators
Authors:Martina Maisel,Hans-Jö  rg Habisch,Loï  c Royer,Javorina Milosevic,Stefan Liebau,Johannes Schwarz,Alexander Storch
Affiliation:a Department of Neurology, Dresden University of Technology, 01307 Dresden, Germany
b Department of Neurology, University of Ulm, 89081 Ulm, Germany
c Department of Clinical Genetics, Dresden University of Technology, 01307 Dresden, Germany
d Bioinformatics, Biotechnology Center (BIOTEC), Dresden University of Technology, 01062 Dresden, Germany
e Institute for Anatomy and Cell Biology, University of Ulm, Germany
f Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopaedics, University of Ulm, 89081 Ulm, Germany
g Department of Neurology, University of Leipzig, 04103 Leipzig, Germany
h Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany
i Center for Regenerative Therapies Dresden (CRTD), Dresden University of Technology, 01307 Dresden, Germany
Abstract:
Keywords:Gene expression profile   Neural stem cells   Neural progenitors   Mesenchymal stem cells   Neuroectodermal conversion   Hypoxia-inducible factor 1α (HIF-1α)   MicroRNA-124a
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