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| 悬尾应激对小鼠空间记忆及其反转学习的损伤效应 | |
| 引用本文： | Wang XQ,Wang GW,Duan QY,Teng ST. 悬尾应激对小鼠空间记忆及其反转学习的损伤效应[J]. 动物学研究, 2011, 32(4): 428-434. DOI: 10.3724/SP.J.1141.2011.04428 |
| 作者姓名： | Wang XQ Wang GW Duan QY Teng ST |
| 作者单位： | 1. 云南师范大学体育学院,云南昆明650500; 2. 云南师范大学生命科学学院行为与认知神经生物学实验室,云南昆明650500;生物能源持续开发利用教育部工程研究中心和云南省生物质能与环境生物技术重点实验室,云南昆明650500 3. 云南师范大学生命科学学院行为与认知神经生物学实验室,云南昆明,650500 |
| 基金项目： | 中国科学院“西部之光”人才培养计划项目(2008); 云南省运动人体科学实验教学示范中心建设项目(2009); 国家自然科学基金项目(31060142) |
| 摘 要： | 该文探讨了连续数天短时悬尾应激对小鼠十字迷宫空间记忆及其反转学习的作用。81只成年雄性昆明小鼠被分为4大组:绝对空间记忆获得组及巩固组;相对空间记忆获得组及巩固组。每大组又分为悬尾组(每天训练前或训练后立即接受悬尾处理20min)和对照组。结果表明,在空间记忆训练初期,各对照组和悬尾组动物正确反应率无明显差异,均在机遇水平;随着训练天数的增加,对照组成绩显著提高,当其正确反应率达到80%时,悬尾组正确反应率仍处于或略高于机遇水平,两组间差异显著(P<0.01);在反转学习中,悬尾组正确反应率也显著低于对照组(P<0.01)。这些表明,悬尾应激可显著损伤小鼠的空间记忆及其反转学习的获得和巩固,其中相对空间记忆及其反转学习的巩固受损尤为严重。 |
| 关 键 词： | 悬尾应激 空间记忆 反转学习 获得 巩固 KM小鼠 |
Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice |
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| Wang Xiao-Qin,Wang Gong-Wu,Duan Qiu-Yan,Teng Shi-Tong. Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice[J]. Zoological Research, 2011, 32(4): 428-434. DOI: 10.3724/SP.J.1141.2011.04428 | |
| Authors: | Wang Xiao-Qin Wang Gong-Wu Duan Qiu-Yan Teng Shi-Tong |
| Affiliation: | WANG Xiao-Qin1,WANG Gong-Wu2,3,*,DUAN Qiu-Yan2,TENG Shi-Tong2(1.School of Physical Education,Yunnan Normal University,Kunming 650500,China,2.Laboratory of Behavioral and Cognitive Neurobiology,School of Life Sciences,3.Engineering Research Center of Sustainable Development and Utilization of Biomass,Ministry of Education & Key Laboratory of Yunnan for Biomass Energy and Biotechnology of Environment,China) |
| Abstract: | Present work investigated the effects of tail suspension stress(TSS) on spatial memory acquisition,consolidation,and its reversal learning in mice.Eighty-one adult male KM mice were divided into four groups(each group including a TSS subgroup and its control subgroup):absolute spatial memory acquisition and consolidation groups(group AA and CA);relative spatial memory acquisition and consolidation groups(group AR and CR).TSS(20 min) was performed immediately before(acquisition) or after(consolidation) a dai... |
| Keywords: | Tail suspension stress Spatial memory Reversal learning Acquisition Consolidation KM mice |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |