Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease |
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| Authors: | K J Reinikainen P J Riekkinen T Halonen M Laakso |
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| Affiliation: | 1. Dept. of Neurology, University of Kuopio, P.O.Box 6, SF-70211 Kuopio, Finland;2. Dept. of Medicine, University of Kuopio, P.O.Box 6, SF-70211 Kuopio, Finland;1. Donald W. Reynolds Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA;2. Geriatric Research Education and Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA;3. Department of Pathology, University of Toledo Health Sciences Campus, Toledo, OH, USA |
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| Abstract: | Muscarinic (cholinergic) receptor binding sites (MRB) were studied by determining the 3H-QNB binding in four cortical areas and hippocampus of 20 histologically confirmed Alzheimer patients and comparing these with corresponding controls. Alzheimer patients dying at younger age (less than or equal to 80) with profound decrease in choline-acetyltransferase activity (by 61-85%) and without any, possibly MRB modifying, drug treatment showed 30% decrease in MRB in the frontal cortex (p less than 0.05), 28% in the temporal cortex (p less than 0.05) and 37% in the hippocampus (p less than 0.01). These findings further suggest that muscarinic receptors are affected in Alzheimer's disease, at least in advanced state of the disease. |
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