Geomagnetic field modulates artificial static magnetic field effect on arterial baroreflex and on microcirculation |
| |
Authors: | Juraj Gmitrov |
| |
Institution: | (1) Department of Environmental Health, National Institute of Public Health, Tokyo 108, Japan;(2) Pro Vitae Hospital, Gelnica, 056 01, Slovak Republic;(3) Visnova 6, Presov, 080 01, Slovak Republic |
| |
Abstract: | Spreading evidence suggests that geomagnetic field (GMF) modulates artificial magnetic fields biological effect and associated
with increased cardiovascular morbidity. To explore the underlying physiological mechanism we studied 350 mT static magnetic
field (SMF) effect on arterial baroreflex-mediated skin microcirculatory response in conjunction with actual geomagnetic activity,
reflected by K and K
p
indices. Fourteen experiments were performed in rabbits sedated by pentobarbital infusion (5 mg/kg/h). Mean femoral artery
blood pressure, heart rate, and the ear lobe skin microcirculatory blood flow, measured by microphotoelectric plethysmogram
(MPPG), were simultaneously recorded before and after 40 min of NdFeB magnets local exposure to sinocarotid baroreceptors.
Arterial baroreflex sensitivity (BRS) was estimated from heart rate/blood pressure response to intravenous bolus injections
of nitroprusside and phenylephrine. We found a significant positive correlation between SMF-induced increase in BRS and increment
in microvascular blood flow (ΔBRS with ΔMPPG, r=0.7, p<0.009) indicated the participation of the arterial baroreflex in the regulation of the microcirculation and its enhancement
after SMF exposure. Geomagnetic disturbance, as opposed to SMF, decreased both microcirculation and BRS, and counteracted
SMF-induced increment in microcirculatory blood flow (K-index with ΔMPPG; r
s=−0.55, p<0.041). GMF probably affected central baroreflex pathways, diminishing SMF direct stimulatory effect on sinocarotid baroreceptors
and on baroreflex-mediated vasodilatatory response. The results herein may thus point to arterial baroreflex as a possible
physiological mechanism for magnetic-field cardiovascular effect. It seems that geomagnetic disturbance modifies artificial
magnetic fields biological effect and should be taken into consideration in the assessment of the final effect.
An erratum to this article can be found at |
| |
Keywords: | Baroreflex sensitivity Geomagnetic disturbance K index Cardiovascular risk |
本文献已被 PubMed SpringerLink 等数据库收录! |
|