Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins |
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| Authors: | Patrick Meraldi Andrew D McAinsh Esther Rheinbay Peter K Sorger |
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| Affiliation: | (1) Department of Biology, Massachusetts Institute of Technology, Massachusetts Ave., Cambridge, MA 02139, USA;(2) Institute of Biochemistry, ETH Zurich, Schafmattstr.,18, CH-8093 Zurich, Switzerland;(3) The Chart, Oxted, Chromosome Segregation Laboratory, Marie Curie Research Institute, Surrey, RH8 0TL, UK |
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| Abstract: | Background Kinetochores are large multi-protein structures that assemble on centromeric DNA (CEN DNA) and mediate the binding of chromosomes to microtubules. Comprising 125 base-pairs of CEN DNA and 70 or more protein components, Saccharomyces cerevisiae kinetochores are among the best understood. In contrast, most fungal, plant and animal cells assemble kinetochores on CENs that are longer and more complex, raising the question of whether kinetochore architecture has been conserved through evolution, despite considerable divergence in CEN sequence. |
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