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Functional assessment of cryopreserved human aortas for pharmaceutical research |
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| Authors: | Ma Esther Rendal Vázquez M Rodríguez Cabarcos MV Martínez Santos RO Fernández Mallo J Sánchez Ibáñez R Segura Iglesias G Matheu Capó P Filgueira Fernández S Pértega Díaz T Bermúdez González C Andión Núñez |
| Institution: | 1. Cryobiology Unit, Complejo Hospitalario Juan Canalejo-Teresa Herrera, 15006, La Coru?a, Spain 2. Transplant Coordination Office, Complejo Hospitalario Juan Canalejo-Teresa Herrera, 15006, La Coru?a, Spain 3. Department of Vascular Surgery, Complejo Hospitalario Juan Canalejo-Teresa Herrera, 15006, La Coru?a, Spain 4. Pathology Department, Complejo Hospitalario Juan Canalejo-Teresa Herrera, 15006, La Coru?a, Spain 5. Statistics Department, Complejo Hospitalario Juan Canalejo-Teresa Herrera, 15006, La Coru?a, Spain |
| Abstract: | We evaluated the impact of standard cryopreservation on functional properties of human aortic homografts. From seven human donors, the thoracic descending aorta was obtained. Effects of cryopreservation on contractibility and endothelium function were tested. After cryopreservation no endothelium-dependent or endothelium-independent relaxation was found and the contractibility was strongly affected. Arteries showed no function and loss of endothelial integrity after cryopreservation and thawing. |
| Keywords: | Contractibilty responses Cryopreservation Endothelium dependent relaxant responses Endothelium independent relaxant responses Vascular Segment |
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