Coexistence of Intraspecies and Interspecies Specific Antigenic Determinants on the Major Structural Polypeptide of Mammalian C-type Viruses |
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Authors: | RAYMOND V. GILDEN STEPHEN OROSZLAN ROBERT J. HUEBNER |
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Affiliation: | 1.Flow Laboratories, Inc.,Rockville;2.Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health,Bethesda |
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Abstract: | THE report of a shared viral antigen (termed gs-3) among mammalian C-type viruses from four species1, extending an earlier report of cross reactivity between mouse and cat viral antigens2, has far reaching implications in the search for human cancer viruses or their gene products. The report is confirmed both by the data presented here and also by the data obtained by another laboratory3. Our gel diffusion assays using various selected sera against mouse, hamster and cat crude and purified C-type viral antigens indicate that the cross reactive antigenic determinants are specifically present on the major structural polypeptide of C-type viruses. The polypeptide also carries species specific determinants. These conclusions are drawn from complement fixation and gel diffusion tests using six types of antisera (either individual sera or pools) prepared as described in Table 1. |
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