Stereospecific synthesis of a novel series of pyridine nucleosides |
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Authors: | Eddy J Freyne Eddy L Esmans Josef A Lepoivre Frank C Alderweireldt |
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Institution: | University of Antwerp (RUCA), Laboratory of Organic Chemistry, Groenenborgerlaan, 171, B 2020 Antwerp Belgium |
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Abstract: | Condensation of chloride severally with 3-acetyl-5-alkylpyridines, 5-alkyl-3-methoxycarbonylpyridines (alkyl = Me, Et, Pr, and iPr), 5-isopropylnicotinamide, and 3,5-diacetylpyridine bis(ethylene acetal) in acetonitrile at ?5° gave the corresponding pyridinium chlorides in excellent yield (90%). From the reaction of a series of halides with 3-acetyl-5-methyl-pyridine at room temperature, the α-nucleosides were obtained. |
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