多形拟杆菌对肥胖大鼠减肥影响的初步研究及毒性实验

目的研究人体肠道内的多形拟杆菌对肥胖大鼠的减肥作用。方法从人体肠道中提取、分离和鉴定1株多形拟杆菌。建立高能饲料诱发的大鼠肥胖模型,给大鼠灌胃多形拟杆菌菌液,25 d后观察大鼠体重及肠道内多形拟杆菌的数量变化。结果灌胃多形拟杆菌菌液的给药组的大鼠体重与灌胃生理盐水的模型组相比,增长慢（P〈0.05）,差异有显著性,且体内拟杆菌数量多于模型组,差异有显著性（P〈0.05）。结论提示多形拟杆菌菌液对肥胖大鼠有一定的减肥作用。

The preliminary study on the effect of Bacteroides thetaiotaomicron on weight control in rats and toxicity test

Objective To preliminaril study the effect of Bacteroides thetaiotaomicron on weight control in Obese rats.Method A strain of Bacteroides thetaiotaomicron was extracted,separated and identified from human intestine.High-energy feed-induced rat models of obesity were built,and intragastriced with the liquid of Bacteroides thetaiotaomicron.After 25 days,the weight and change in the number of Bacteroides thetaiotaomicron were observed.Result The body weight of the group intragastriced with the liquid of Bacteroides thetaiotaomicron,increased more slouly compared with that of the group intragastrieed with saline, solution, while the number of Bacteroides thetaiotaomicron of the former was more then that of the latter group. The differences were significant （ P 〈 0. 05）. Conclusion Bacteroides thetaiotaomicron has a certain effect of weight reduction in obese rats.