Don't bother to knock--the cell invasion strategy of Trypanosoma cruzi |
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Authors: | Tan Henry Andrews Norma W |
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Institution: | Section of Microbial Pathogenesis and Dept of Cell Biology, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA. |
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Abstract: | The protozoan parasite Trypanosoma cruzi is responsible for Chagas disease, a serious debilitating disease that affects millions of people in Latin America. Trypomastigotes, the infective forms, are capable of invading and replicating in different cell types. The invasion process involves a gradual recruitment and fusion of host cell lysosomes at the parasite entry site, and is regulated by intracellular free Ca2+ transients triggered by trypomastigotes in host cells. This unusual, Ca2+-dependent lysosome exocytosis pathway was recently shown to be involved in the mechanism by which mammalian cells repair lesions on their plasma membrane. |
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