Characterization of diorganotin(IV) complexes with captopril. The first crystallographically authenticated metal complex of this anti-hypertensive agent |
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Authors: | Jankovics Hajnalka Pettinari Claudio Marchetti Fabio Kamu Erzsébet Nagy László Troyanov Sergei Pellerito Lorenzo |
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Institution: | Biocoordination Research Group of Hungarian Academy of Sciences, Department of Inorganic and Analytical Chemistry, University of Szeged, P.O. Box 440, H-6701, Szeged, Hungary. |
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Abstract: | Diorganotin(IV) complexes R(2)Sn(cap) (capH(2)=N-(S)-3-mercapto-2-methylpropionyl]-L-proline; R=Me, Et, n-Bu and t-Bu) were prepared and characterised. The FTIR and Raman spectra demonstrated that the organotin(IV) moieties interact with the S] atom of the ligand, while the other coordination sites are the carboxylate and the amide -CO groups. M?ssbauer Delta data showed that the diorganotin(IV) compounds adopt slightly distorted trigonal-bipyramidal (tbp) geometry. A single-crystal X-ray study was performed on the compound Me(2)Sn(cap): the Sn atom is five-coordinated in a distorted tbp environment, with two O] atoms in the axial positions and the S] and two C] atoms in the equatorial (eq) plane. Each cap ligand coordinates to two different Sn atoms, and infinite zigzag chains are formed, directed parallel to each other and to the b axis of the unit cell. NMR (CDCl(3)) of the Me(2)Sn(IV) and n-Bu(2)Sn(IV) complexes indicated the presence of different oligomeric species. |
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