Conformational flexibility in physiologically active amines. |
| |
Authors: | W G Richards D G Aschman J Hammond |
| |
Affiliation: | Physical Chemistry Laboratory, South Parks Road, Oxford, England |
| |
Abstract: | Physiologically active amines are flexible molecules which could use this conformational freedom to adapt their shapes when binding to receptor molecules. Calculations of conformational freedom indicate which substituted analogues could serve as experimental tests of the hypothesis that the flexibility of the natural transmitters is an essential feature of activity. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |