1H, 13C and 15N resonance assignment of 6aJL2(R25G), a highly fibrillogenic λVI light chain variable domain |
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| Authors: | Luis H Gutiérrez-González Lucia Muresanu Luis del Pozo-Yauner Rosalba Sánchez Leopoldo Guereca Baltazar Becerril Christian Lücke |
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| Institution: | (1) Laboratorio de Ingeniería Genética y Metabolitos Secundarios, Departamento de Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, 09340, Mexico;(2) Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, 06120 Halle (Saale), Germany;(3) Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, 62210, Mexico |
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| Abstract: | An allotypic variation at position 25 influences the fibrillogenicity of λVI light chains, which are related to humoral immune
response and have been associated with AL amyloidosis. The full resonance assignment and a preliminary structural characterization
of 6aJL2(R25G) are reported.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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| Keywords: | Immunoglobulin AL amyloidosis Hypervariable loops |
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