Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro |
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| Authors: | Sanz-Cervera J F Stocking E M Usui T Osada H Williams R M |
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| Institution: | Departamento de Química Orgánica, Universidad de Valencia, Spain. |
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| Abstract: | The synthesis of three isoprenylated derivatives of cyclo-L-Trp-L-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly. |
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