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New antibiotic with typical plant anthraquinone structure obtained studying terrestrial and marine Streptomycetes |
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| Authors: | Hong Xia Cui Khaled A. Shaaban Mirko Schiebel Song Qin Hartmut Laatsch |
| Affiliation: | 1. College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, P. R. China 2. Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, P. R. China 3. Department of Organic and Biomolecular Chemistry, University of G?ttingen, Tammannstrasse 2, D-37077, Gottingen, Germany |
| Abstract: | In our screening for new antibiotics from bacteria, the streptomycete isolate M097 from Jiaozhou Bay in China was found to produce aloesaponarin II (1a) and 1,6-dihydroxy-8-hydroxymethyl-anthraquinone (2). Similarly, a terrestrial streptomycete GW24/1694 produced 1a and its methyl ether, the new compound 1-hydroxy-6-methoxy-8-methyl-anthraquinone (1b). All structures were derived by spectrochemical analysis and by comparison with reference data. The results showed that the marine streptomycete isolate M097 and the terrestrial streptomycete GW24/1694 could be a promising material for studying the biosynthetic pathway of polyketides. |
| Keywords: | Streptomycetes 1,6-Dihydroxy-8-hydroxymethyl-anthraquinone 1-Hydroxy-6-methoxy-8-methyl-anthraquinone Aloesaponarin II |
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