New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone |
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| Authors: | Hsiao P.J. Voon Lee H. Wong |
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| Affiliation: | Department of Biochemistry and Molecular Biology, The Biomedicine Discovery Institute, Monash University, Wellington Road, Clayton, Victoria 3800, Australia |
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| Abstract: | A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome. |
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