Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression |
| |
Authors: | Aja Susan Ewing Cassandra Lin Jennifer Hyun Jayson Moran Timothy H |
| |
Affiliation: | Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA. saja1@jhmi.edu |
| |
Abstract: | Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 microg EX blocked the feeding inhibitory action of 1 microg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|