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No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population |
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| Authors: | Logan Dumitrescu Cara L Carty Nora Franceschini Lucia A Hindorff Shelley A Cole Petra B??ková Fredrick R Schumacher Charles B Eaton Robert J Goodloe David J Duggan Jeff Haessler Barbara Cochran Brian E Henderson Iona Cheng Karen C Johnson Chris S Carlson Shelly-Anne Love Kristin Brown-Gentry Alejandro Q Nato Miguel Quibrera Ralph V Shohet José Luis Ambite Lynne R Wilkens Loïc Le Marchand Christopher A Haiman Steven Buyske Charles Kooperberg Kari E North Myriam Fornage Dana C Crawford |
| Institution: | 1. Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 515B Light Hall, Nashville, TN, 37232, USA 2. Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA 3. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA 4. Office of Population Genomics, National Human Genome Research Institute, Bethesda, MD, USA 5. Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA 6. Department of Biostatistics, University of Washington, Seattle, WA, USA 7. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 8. Department of Family Medicine, Warren Alpert Medical School Brown University, Providence, RI, USA 9. Translational Genomic Science Institute, Phoenix, AZ, USA 10. Baylor College of Medicine, Houston, TX, USA 11. Cancer Research Center, University of Hawaii, Honolulu, HI, USA 12. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA 13. Department of Genetics, Rutgers University, Piscataway, NJ, USA 14. Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA 15. John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA 16. Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA 17. Department of Statistics, Rutgers University, Piscataway, NJ, USA 18. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 19. Division of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, USA 20. Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA 21. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA |
| Abstract: | Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions. |
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