Homeostatic synaptic scaling is regulated by protein SUMOylation |
| |
Authors: | Craig Tim J Jaafari Nadia Petrovic Milos M Rubin Philip P Mellor Jack R Henley Jeremy M |
| |
Institution: | Medical Research Council Centre for Synaptic Plasticity, School of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom. |
| |
Abstract: | Homeostatic scaling allows neurons to alter synaptic transmission to compensate for changes in network activity. Here, we show that suppression of network activity with tetrodotoxin, which increases surface expression of AMPA receptors (AMPARs), dramatically reduces levels of the deSUMOylating (where SUMO is small ubiquitin-like modifier) enzyme SENP1, leading to a consequent increase in protein SUMOylation. Overexpression of the catalytic domain of SENP1 prevents this scaling effect, and we identify Arc as a SUMO substrate involved in the tetrodotoxin-induced increase in AMPAR surface expression. Thus, protein SUMOylation plays an important and previously unsuspected role in synaptic trafficking of AMPARs that underlies homeostatic scaling. |
| |
Keywords: | Ionotropic Glutamate Receptors (AMPA/NMDA) Neurons Post-translational Modification Sumoylation Synaptic plasticity |
本文献已被 PubMed 等数据库收录! |
|