Regulation of the 4-hydroxyphenylacetic acid meta-cleavage pathway in an Acinetobacter sp |
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Authors: | M G Barbour R C Bayly |
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Institution: | Department of microbiology, monash university medical school, commercial road, Prahran, Victoria, 3181, Australia |
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Abstract: | Lactate-grown cultures of sp. strain 3B-1 synthesize constitutively all enzymes except the 4-hydroxyphenylacetic acid-3-hydroxylase. All enzymes are further synthesized when strain 3B-1 is grown with 4-hydroxyphenylacetic acid. Induction studies with two mutant strains, one defective in the 3-hydroxylase, and the other defective in the dehydrogenase, indicate that 4-hydroxyphenylacetic acid induces the 3-hydroxylase only, and the second metabolite 3,4-dihydroxyphenylacetic acid appears to induce 3,4-dihydroxyphenylacetic acid-2,3-dioxygenase and subsequent enzymes. Thus, the enzymes of the 4-hydroxyphenylacetic acid -cleavage pathway are synthesized following at least two sequential inductive events. |
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