Changes in blood chemistry, hematology, and histology caused by a selenium/vitamin E deficiency and recovery in chicks |
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Authors: | Amy Bartholomew David Latshaw David E Swayne |
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Institution: | (1) Department of Animal Sciences, Ohio State University, 43210 Columbus, OH;(2) USDA/ARS/SEPRL, Athens, GA |
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Abstract: | Exudative diathesis, a condition caused by a selenium (Se)/vitamin E deficiency, was studied in chicks. Trios of chicks that
showed clinical signs of exudative diathesis were matched for severity. One was injected subcutaneously with 0.5 mL distilled
water, and the other two received 15 μg of Se in 0.5 mL distilled water. A chick fed a diet with supplemental Se also received
0.5 mL distilled water. Blood was collected from three chicks 2 d after injection, and from the other chick, 6 d after injection.
After blood was collected, pectoral muscle and bone marrow were collected. Deficient chicks showed varying degrees of necrosis
in pectoral muscle, whereas recovring chicks had extensive fibrosis in pectoral muscle. An analysis of blood showed differences
in CO2, glucose, Se, glutathione peroxidase, alanine aminotransferase, aspartate aminotransferase, and creatine kinase. Heterophils
and monocytes were increased in deficient chicks; lymphocytes, basophils, and hemoglobin decreased. After 6 d of recovery,
all of the changes noted above were correcting toward normal. Eosinophils, in contrast, were unaffected by a deficiency, but
increased in recovering chicks. It is hypothesized that cytokines associated with the inflammatory response accentuate the
clinical signs of exudative diathesis. |
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Keywords: | Chicks selenium inflammatory response necrosis exudative diathesis |
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