Ectopic pairing of chromosome regions containing chemically similar DNA |
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| Authors: | Dr. H. J. Barr Dr. John R. Ellison |
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| Affiliation: | (1) Department of Anatomy, University of Wisconsin, Madison;(2) Center for Genetics, Medical Center, University of Illinois, 60612 Chicago, Ill., USA;(3) Present address: Department of Biological Sciences, Carnegie-Mellon University, 15213 Pittsburgh, Pa., USA |
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| Abstract: | Using genetically controlled stocks ofDrosophila melanogaster we have compared the frequency of ectopic pairing in a line showing intense quinacrine fluorescence at two sites (81F and 83E) on chromosome 3 with one showing such fluorescence at only one of these sites (81F). The frequency of ectopic pairing is an order of magnitude greater in cells from the line showing intense fluorescence in both regions than in the line showing it in only one. These data indicate that ectopic pairing is dependent upon properties of discrete chromosome regions as small as individual bands. Since A: T-rich chromatin is known to fluoresce intensely after quinacrine staining, these data further suggest that ectopic pairing is dependent on similarities of the DNA of the discrete chromosome regions involved. |
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