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Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes |
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| Authors: | Eve Gazave Pascal Lapébie Gemma S Richards Frédéric Brunet Alexander V Ereskovsky Bernard M Degnan Carole Borchiellini Michel Vervoort Emmanuelle Renard |
| Affiliation: | 1. Centre d'Océanologie de Marseille, Aix-Marseille Universités, Station marine d'Endoume - CNRS UMR 6540-DIMAR, rue de la Batterie des Lions, 13007, Marseille, France 2. School of Biological Sciences, University of Queensland, 4072, Brisbane, QLD, Australia 3. Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS UMR 5242, INRA, IFR128 BioSciences Lyon-Gerland, Ecole Normale Supérieure de Lyon, 46, Allée d'Italie, 69007, Lyon, France 4. Department of Embryology, Faculty of Biology and Soils, Saint-Petersburg State University, Universitetskaja nab. 7/9, St Petersburg, Russia 5. Institut Jacques Monod, UMR 7592 CNRS/Université Paris Diderot - Paris 7, 15 rue Hélène Brion, 75205, Paris Cedex 13, France 6. UFR de Biologie et Sciences de la Nature, Université Paris 7 - Denis Diderot, 2 place Jussieu, 75251, Paris Cedex 05, France |
| Abstract: | BackgroundOf the 20 or so signal transduction pathways that orchestrate cell-cell interactions in metazoans, seven are involved during development. One of these is the Notch signalling pathway which regulates cellular identity, proliferation, differentiation and apoptosis via the developmental processes of lateral inhibition and boundary induction. In light of this essential role played in metazoan development, we surveyed a wide range of eukaryotic genomes to determine the origin and evolution of the components and auxiliary factors that compose and modulate this pathway. |
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