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Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sj?gren's syndrome in salivary glands of non-obese diabetic mice |
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| Authors: | Margaret K Gatumu Kathrine Skarstein Adrian Papandile Jeffrey L Browning Roy A Fava and Anne Isine Bolstad |
| Institution: | (1) Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Jonas Lies vei 65, N-5021 Bergen, Norway;(2) Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA;(3) Department of Veterans Affairs Medical Center, 215 North Main Street, 05009 White River Junction, VT, USA;(4) Department of Micro/Immunology, Dartmouth Medical School, 1 Rope Ferry Road, 03756 Hanover, NH, USA;(5) Department of Clinical Dentistry – Periodontics, University of Bergen, Aarstadveien 17, N-5009 Bergen, Norway |
| Abstract: | IntroductionThe lymphotoxin-beta receptor (LTβR) pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases such as diabetes and rheumatoid arthritis. The aim of this study was to determine the effects of LTβR pathway blockade on Sj?gren syndrome (SS)-like salivary gland disease in non-obese diabetic (NOD) mice. |
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