Antimicrobial beta-peptoids by a block synthesis approach |
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Authors: | Shuey Steven W Delaney William J Shah Mukesh C Scialdone Mark A |
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Affiliation: | DuPont Central Research and Development, PO Box 80328, Experimental Station, Wilmington, DE 19880-0328, USA. Steven.W.Shuey@usa.dupont.com |
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Abstract: | Antimicrobial peptides and their mimetics offer a potential new disinfective tool. beta-Peptoids (oligo-N-substituted beta-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-beta-peptoids were first prepared and then ligated via amide bond formation to synthesize larger beta-peptoids was developed. The beta-peptoids were found to possess moderate activity in an Escheridchia coli assay. |
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