TRPM7 reflected in Cryo-EMirror |
| |
| Institution: | 1. Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Germany;2. German Center for Lung Research, Munich, Germany;3. German Centre for Cardiovascular Research, Munich Heart Alliance, Munich, Germany;1. Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, 80336, Munich, Germany;2. Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University of Munich, 80336, Munich, Germany;3. DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany;4. German Center for Lung Research, Munich, Germany;1. M. V. Lomonosov Moscow State University, Moscow, Russia;2. National Research Tomsk State University, Tomsk, Russia;3. Siberian Medical State University, Tomsk, Russia;4. Department of Molecular Medicine and Surgery, Karolinska Institutet, Sweden;1. Institute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area & Hubei Medical Biology International Science and Technology Cooperation Base, College of Life Sciences, South-Central University for Nationalities, Wuhan, 430074, China;2. Department of Biomedical Engineering, School of Medicine & School of Engineering, University of Alabama Birmingham, AL, 35294, USA;3. Wuhan Institute for Neuroscience and Engineering, South-Central University for Nationalities, Wuhan, 430074, China |
| |
| Abstract: | TRPM7 is an atypical type of ion channel because its pore-forming moiety is covalently linked to a protein kinase domain. The channel-kinase TRPM7 controls a wide range of biological processes such as mineral homeostasis, immune responses, cell motility, proliferation and differentiation. Earlier this year, Duan J & co-workers 1] published three TRPM7 structures resolved by cryo-electron microscopy (cryo-EM). This study tremendously advances our mechanistic understanding of TRPM7 channel function and forms the basis for informed structure-function assessment of this extraordinary protein. |
| |
| Keywords: | TRP channels TRPM7 TRPM6 TRPM2 Magnesium |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
