Evidence for archaic Asian ancestry on the human X chromosome |
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Authors: | Garrigan Daniel Mobasher Zahra Severson Tesa Wilder Jason A Hammer Michael F |
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Affiliation: | * Division of Biotechnology, and Department of EEB, University of Arizona, Tucson |
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Abstract: | The human RRM2P4 pseudogene has a pattern of nucleotide polymorphism that is unlike any locus published to date. A gene tree constructed from a 2.4-kb fragment of the RRM2P4 locus sequenced in a sample of 41 worldwide humans clearly roots in East Asia and has a most-recent common ancestor approximately 2 Myr before present. The presence of this basal lineage exclusively in Asia results in higher nucleotide diversity among non-Africans than among Africans. A global survey of a single-nucleotide polymorphism that is diagnostic for the basal, Asian lineage in 570 individuals shows that it occurs at frequencies up to 53% in south China, whereas only one of 177 surveyed Africans carries this archaic lineage. We suggest that this ancient lineage is a remnant of introgressive hybridization between expanding anatomically modern humans emerging from Africa and archaic populations in Eurasia. |
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Keywords: | hybridization human origins polymorphism population subdivision pseudogene |
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